Driving Innovation in CNS Drug Discovery
Neuroscience is a broad area that includes neuroinflammatory and neurodegenerative diseases, psychiatric disorders, epilepsy and pain. So far, current treatments focus mainly on relieving symptoms than curing the disease and have both use and efficacy limitations. Disease understanding and identification of new potential targets for therapeutic interventions are highlights in the current Neuroscience research and CNS drug discovery field.
Benefits of Choosing Eurofins Discovery for CNS Research
At Eurofins Discovery, our team of experts possess deep expertise and extensive experience in CNS drug discovery research. We have a proven track record of advancing multiple clinical candidates, utilizing our comprehensive skills from in vitro to in vivo applications. Our translational approach spans from target-based biochemical and cellular assays to disease-relevant primary cellular systems. We specialize in:
- Potency assessment in target-based and phenotypic assays
- Building customized cell models relevant for the disease mechanism of interest
- Neurodegeneration assay panel using disease mutant variants
- CNS safety dedicated panels and neurotoxicity assays in IPSC-derived neurons
- Designing brain penetrant compounds
- Identifying key target modulation biomarkers and brain penetration (Kp,uu)
- Establishing PK/PD relationships through in vivo biomarker measurement
- Demonstrating efficacy in our in vivo pharmacology models or with third party specialist providers
- Flexible pricing models, both Fee-for-Service (FFS) and Full Time Equivalent (FTE) solutions available
Partnering with us ensures expert guidance and flexibility throughout your program, facilitating rapid and efficient project progression.
Contact Us to Move Your CNS Research Forward
With our innovative solutions and deep understanding of CNS diseases, Eurofins Discovery is your ideal partner for your CNS drug discovery. Contact us today to learn how we can help you achieve your research goals and expedite the discovery of effective therapeutics.
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Key Features of Our Neuroscience Solutions
Innovative In Vitro Pharmacology
- Phenotypic readout in cellular assays expressing human disease mutants
- Disease assays using human IPSC-derived neurons, microglia, primary cell cultures, cell lines
- Neuroprotective assays using disease-relevant insults (e.g MPP+, 6-OHDA and lactacystin)
- Multiple Readouts/technologies in our Cell-Based Labs to suit your needs: High Content Imaging, Calcium Imaging, FACS, ELISA, AlphaLISA, Mesoscale, Luminex
- Electrophysiology: manual patch-clamp, ion channel screening (Qube), and MEA
Advanced Translational Biology Screening
- Custom mechanism of action studies: mitochondria biology, cytokine secretion, autophagy, apoptosis, phagocytosis in relevant cell types: primary neurons, iPSC-derived microglia
- Cutting-Edge Biomarker Services: target engagement in donor PBMC, serum, plasma, CSF
- Brain homogenate binding and Kpuu determination
- Predicting brain permeability using MDR1-MDCKII cells
- HTS and LO Support: Utilize relevant disease-relevant cell types, and readouts
Comprehensive In Vivo Pharmacology Models
- Behavioral endpoints e.g. thermal hyperalgesia, mechanical allodynia
- Anhedonia, reward, motivation and cognitive function assessment
- Pain models: acute, inflammatory, neuropathic pain, migraine
- Efficacy models (epilepsy, neurodegeneration)
- CNS safety testing and neurological screening
