Quantitate compound binding affinity against any kinase assay. Inhibitor binding constants (Kd values) are calculated from duplicate 11-point dose-response curves. Measurements are made under optimized conditions that generate true thermodynamic Kd values which facilitate direct comparison of inhibitor affinity across kinases.
KdELECT may be used as a follow-up study tool to quantify binding affinity of compound-kinase interactions identified in primary screens, to supplement existing data, or support lead optimization and SAR activity.
Panel Features & Benefits
- 11-point dose response curve in duplicate
- Broad dynamic range: can detect compounds with Kds <100 pM to >10uM
- Rapid turnaround time: 5 business days*
- Flexible
- Quantify binding to inactive or low activity kinases
*Eligible projects are activated every day. Data report is delivered on or before the fifth day after project begins. Premium services of 72-hour complete data delivery are available, please inquire with your account manager.
