PNMT Phenylethanolamine N-Methyltransferase Human SMMT Mass Spectrometry Enzymatic LeadHunter Assay - FR

Background Information:

Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that catalyzes the S-adenosyl-methionine (AdoMet)-dependent methylation of norepinephrine to epinephrine in the adrenal medulla but occurs in other tissues throughout the body i.e. brain, eye, spinal cord, lung, kidney, heart, liver, spleen and pancreas. PNMT plays role in trace amine and catecholamine biosynthesis concerned with the regulation of automatic function, heart rate, blood pressure, blood glucose. PNMT may be regulated neutrally via the stimulation of the splanchnic nerve and hormonally via the hypothalamic-pituitary-adrenal axis and positively influenced by glucocorticoids. PNMT inhibitor might be useful in the treatment of hypertension, metabolic and hormonal responses.

Family:

Neurotransmitter Metabolism

Sub Family:

Catecholamine Turnover

Protein Name:

Phenylethanolamine N-Methyltransferase

Uniprot Number:

P11086

Gene Name:

PNMT

Gene ID:

5409

Accession Number:

NM_002686

Organism:

Human

Construct Details:

Recombinant