DP2 Human Prostanoid GPCR Cell Based Agonist cAMP LeadHunter Assay - US

Background Information:

Prostanoid receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Prostaglandin D2 (PGD2), detected in brain, lung, skin, and mast cells, is implicated in the regulation of body temperature, sleep, hormone secretion, ion transport and pain. Prostanoid CRTH2 (Chemoattractant Receptor-homologous molecule expressed on T-Helper type 2 cells) receptor is activated by PGD2 and leads to increase in eosinophils and Th2 cell motility. CRTH2 receptor antagonism may be useful in the treatment of allergic inflammation.

cAMP Hunter™ Gi cell lines overexpress naturally Gi coupled, wild type GPCRs and are designed to detect inhibition of intracellular cAMP production in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Prostanoid

Class:

Class A

Coupling:

Gi/Go

Protein Name:

DP2

Uniprot Number:

Q9Y5Y4

Protein Aliases:

chemoattractant receptor homologous molecule expressed on T helper type 2 cells|G-protein coupled receptor 44|CD antigen CD294

Gene Name:

PTGDR2

Gene ID:

11251

Gene Aliases:

CRTH2|CD294|DP2|DL1R|GPR44

Accession Number:

AY507142

Organism:

Human

Cell Type:

CHO-K1